Short Course Description

Mass Spectrometry in Drug Discovery, Proteomics, and Metabolomics

This course offers an overview of mass spectrometry with applications in proteomics, metabolomics, and drug discovery. Typical attendees include scientists, engineers, managers, investors, students and sales professionals.

Who Should Attend

Anyone seeking an introduction to the field of mass spectrometry, instrumentation, and applications in proteomics, metabolomics, and drug discovery. A general understanding of a mass spectrometry is helpful. Typical attendees include scientists, engineers, lab managers, marketing and sales professionals, and students.

How You'll Benefit From This Course

• Learn about the most recent technologies developed for proteomics, metabolomics, PK-ADME analysis, and drug discovery
• Obtain a basic understanding of ionization and mass analysis
• Learn why mass spectrometry is one of the most important tools in biology and chemistry
• Learn the methods of generating data from mass spectrometers
• Approaches to data analysis for protein identification and characterization
• Become aware of quantitative analysis for both small molecule metabolites and proteins
• Learn the advantages and limitations of this technology for these specific applications

Course Topics

• How mass spectrometers work (ion trap, quads, ToFs, FTMS)
• Ionization approaches for biological and chemical analysis
• Pharmacokinetics/metabolite profiling and quantitation methods
• Intact protein analysis
• Protein identification and sequencing with MALDI-MS and LC/MS/MS
• Approaches to drug discovery through surface-based mass spectrometry
• Approaches to drug discovery by monitoring non-covalent interactions
• High throughput applications of mass spectrometry
• LC/MS and SFC/MS approaches and applications
• New MS technologies

Course Fee: US $500/$600*

Course Format: Lecture

Class Limit: 40

Instructors:

Mike Greig Pfizer Global R&D — La Jolla San Diego, California USA

Mike Greig, an Associate Research Fellow at Pfizer Global R&D in San Diego, leads Analytical Biology, a core mass spectrometry and NMR group. Before joining Pfizer in 1997, he worked at Revlon Science Institute (La Jolla, CA) as a polymer and analytical chemist and at Isis Pharmaceuticals (Carlsbad, CA) as the Mass Spectrometry Lab Manager. He has over 15 years experience in the field of mass spectrometry and analytical chemistry, analyzing everything from small molecules to polymers to proteins. He has taught mass spectrometry classes at various scientific conferences around the world, was a member of the Lab Automation Scientific Committee, and has over 50 presentations and publications. Specific expertise in high throughput MS systems, software and analysis, oligonucleotide analysis, SFC/MS and LC/MS, FTICR-MS, APPI, and general mass spectrometry.

Gary Siuzdak The Scripps Research Institute La Jolla, California USA

Gary Siuzdak, is Senior Director of the Center for Mass Spectrometry at The Scripps Research Institute where he is also Associate Professor of Molecular Biology. He is the founder of Mass Consortium Corporation (1994), organizer of the San Diego Mass Analysis Network since its inception in 1995, and has authored "Mass Spectrometry for Biotechnology" (1996, Academic Press) and "The Expanding Role of Mass Spectrometry in Biotechnology" (2003, MCC Press and 2006 2nd Edition ). Dr. Siuzdak has over 130 peer-reviewed publications and his research has focused on biochemical applications of mass spectrometry. For more information see http://masspec.scripps.edu/.

* higher fee applies to those who are not ALA members